Development of a miniaturised drug delivery system with wireless power transfer and communication
Development of a miniaturised drug delivery system with wireless power transfer and communication
- Author(s): S. Smith ; T.B. Tang ; J.G. Terry ; J.T.M. Stevenson ; B.W. Flynn ; H.M. Reekie ; A.F. Murray ; A.M. Gundlach ; D. Renshaw ; B. Dhillon ; A. Ohtori ; Y. Inoue ; A.J. Walton
- DOI: 10.1049/iet-nbt:20070022
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- Author(s): S. Smith 1 ; T.B. Tang 1 ; J.G. Terry 1 ; J.T.M. Stevenson 1 ; B.W. Flynn 1 ; H.M. Reekie 1 ; A.F. Murray 1 ; A.M. Gundlach 1 ; D. Renshaw 1 ; B. Dhillon 2 ; A. Ohtori 3 ; Y. Inoue 3 ; A.J. Walton 1
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View affiliations
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Affiliations:
1: Institute of Integrated Micro and Nano Systems, School of Engineering and Electronics, Scottish Microelectronics Centre, The University of Edinburgh, Edinburgh, UK
2: Institute of Integrated Micro and Nano Systems, School of Engineering and Electronics, Scottish Microelectronics Centre, Princess Alexandria Eye Pavilion, Edinburgh, UK
3: Institute of Integrated Micro and Nano Systems, School of Engineering and Electronics, Scottish Microelectronics Centre, Senju Pharmaceutical Co. Ltd, Hyogo, Japan
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Affiliations:
1: Institute of Integrated Micro and Nano Systems, School of Engineering and Electronics, Scottish Microelectronics Centre, The University of Edinburgh, Edinburgh, UK
- Source:
Volume 1, Issue 5,
October 2007,
p.
80 – 86
DOI: 10.1049/iet-nbt:20070022 , Print ISSN 1751-8741, Online ISSN 1751-875X
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The development of an implantable system designed to deliver drug doses in a controlled manner over an extended time period is reported. Key performance parameters are the physical size, the power consumption and also the ability to perform wireless communications to enable the system to be externally controlled and interrogated. The system has been designed to facilitate wireless power transfer, which is very important for miniaturisation as it removes the need for a battery.
Inspec keywords: patient care; medical control systems; drug delivery systems
Other keywords:
Subjects: Patient care and treatment; Biological and medical control systems; Control system design and analysis
References
-
-
1)
- G.T.A. Kovacs , N.I. Maluf , K.E. Petersen . Bulk micromachining of silicon. Proc. IEEE , 1536 - 1551
-
2)
- D. Rodger , J. Weiland , M. Humayan , Y.-C. Tai . Scalable high lead-count parylene package for retinal prostheses. Sens. Actuators B , 1 , 107 - 114
-
3)
- W. Benard , H. Kahn , A. Heuer , M. Huff . Thin-film shape-memory alloy actuated micropumps. IEEE J. Microelectromech. Syst. , 2 , 245 - 251
-
4)
- Zahn, J., Deshmukh, A., Pisano, A., Liepmann, D.: `Continuous on-chip micropumping through a icroneedle', 14thIEEE Int. Conf. Micro Electro Mechanical Systems, MEMS 2001, January 2001, p. 503–506.
-
5)
- R. Frankenthal , D. Siconolfi . The anodic corrosion of gold in concentrated chloride solutions. J. Electrochem. Soc. , 6 , 1192 - 1196
-
6)
- K. Williams , K. Gupta , M. Wasilik . Etch rates for micromachining processing part II. IEEE J. Microelectromech. Syst. , 6 , 761 - 778
-
7)
- N. Stark . Literature review: biological safety of parylene C. Med. Plast. Biomater. , 30 - 35
-
8)
- J.T. Santini , M.J. Cilma , R. Langler . A controlled-release microchip. Nature , 335 - 338
-
9)
- Tang, T., Smith, S., Flynn, B., Stevenson, J., Gundlach, A., Reekie, H., Murray, A., Renshaw, D., Dhillon, B., Ohtori, A., Inoue, Y., Terry, J., Walton, A.: `Implementation of a wireless power transfer and communications system for an Implantable drug delivery system', The 10th Ann. Eur. Conf. Micro and Nanoscale Technologies for the Biosciences (NanoTech 2006), November 2006, Montreux, Switzerland.
-
10)
- Maillefer, D., Gamper, S., Frehner, B., Balmer, P., van Lintel, H., Renaud, P.: `A high performance silicon micropump for disposable drug delivery systems', 14thIEEE Int. Conf. Micro Electro Mechanical Systems, MEMS 2001, January 2001, p. 413–417.
-
11)
- Li, Y., Shawgo, R., Langer, R., Cima, M.: `Mechanical testing of gold membranes on a MEMS device for drug delivery', 2ndAnn. Int. IEEE-EMB Special Topic Conf. on Microtechnologies in Medicine and Biology, May 2002, Madison, WI, USA, p. 390–393.
-
12)
- Laermer, F., Schilp, A., Funk, K., Offenberg, M.: `Bosch deep silicon etching: improving uniformity and etch rate for advanced MEMS applications', Twelfth IEEE Int. Conf. on Micro Electro Mechanical Systems. MEMS ‘99, January 1999, Orlando, FL, USA, p. 211–216.
-
13)
- R. Reay , E. Klaassen , G. Kovacs . Thermally and electrically isolated single crystal silicon structures in CMOS technology. IEEE Electron. Device Lett. , 10 , 399 - 401
-
14)
- B. Humphrey . Using parylene for medical substrate coating. Med. Plast. Biomater. , 28 - 33
-
15)
- S. Wolf , F. Jung , H. Kiesewetter , N. Körber , M. Reim . Video fluorescein angiography: method and clinical application. Graefe's Arch. Clin. Exp. Ophthalmol , 2 , 145 - 151
-
16)
- S. Kingman . Holey chips for drug delivery. Drug Discov. Today , 23 , 1186 - 1187
-
17)
- P. Sinha , G. Valco , S. Sharma , X. Liu , M. Ferrari . Nanoengineered device for drug delivery application. Nanotechnology , S585 - S589
-
18)
- T. Tang , S. Smith , B. Flynn , J. Stevenson , A. Gundlach , H. Reekie , A. Murray , D. Renshaw , B. Dhillon , A. Ohtori , Y. Inoue , J. Terry , A. Walton . Implementation of a wireless power transfer and communications system for an implantable drug delivery system. IEEE Trans. Biomed. Eng.
-
19)
- W. Gorham . Para-xylylene polymers. US Patent Office
-
20)
- Tabata, O., Asahi, R., Funabashi, H., Sugiyama, S.: `Anisotropic etching of silicon in (CH', Int. Conf. Solid-State Sensors and Actuators (Transducers ‘91), Digest of Technical Papers, June 1991, San Francisco, CA, USA, p. 811–814.
-
21)
- J. Prescott , S. Lipka , S. Baldwin , N. Sheppard , J. Maloney , J. Coppeta , B. Yomtov , M. Staples , J. Santini . Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device. Nat. Biotechnol. , 4 , 437 - 438
-
22)
- Schnakenberg, U., Benecke, W., Lange, P.: `TMAHW etchants for silicon micromachining', Digest of Technical Papers; Int. Conf. Solid-State Sensors and Actuators (Transducers ‘91), June 1991, San Francisco, CA, USA, p. 815–818.
-
23)
- D. Reynaerts , J. Peirs , H.V. Brussel . An implantable drug-delivery system based on shape memory alloy micro-acutation. Sens. Actuators A , 455 - 462
-
24)
- B. Merchant . Gold, the noble metal and the paradoxes of its toxicology. Biologicals , 49 - 59
-
25)
- C. Webb . Chip shots. IEEE Spectr. , 10 , 48 - 53
-
26)
- K. Lian , B. Stark , A. Gundlach , A. Walton . Aluminium passivation for TMAH based anisotropic etching for MEMS applications. Electron. Lett. , 15 , 1266 - 1267
-
27)
- J. Maloney , S. Uhland , B. Polito , N. Sheppard , C. Pelta , J. Santini . Electrothermally activated microchips for implantable drug delivery and biosensing. J. Control. Release , 244 - 255
-
28)
- S. Smith , T. Tang , J. Stevenson , B. Flynn , H. Reekie , A. Murray , A. Gundlach , D. Renshaw , B. Dhillon , A. Ohtori , Y. Inoue , A. Walton . Miniaturised drug delivery system with wireless power transfer and communication. Inst. Eng. Technol. Seminar on MEMS Sensors and Actuators , 155 - 162
-
1)