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access icon free Nutratherapeutics approach against cancer: tomato-mediated synthesised gold nanoparticles

© The Institution of Engineering and Technology
Received 21/03/2017, Accepted 25/08/2017, Revised 07/08/2017, Published 25/08/2017

In this study, an eco-friendly biosynthesis of stable gold nanoparticles (T-GNPs) was carried out using different concentrations of tomato juice (nutraceuticals) as a reducing agent and tetrachloroauric acid as a metal precursor to explore their potential application in cancer therapeutics. The synthesis of T-GNPs was monitored by UV-visible absorption spectroscopy, which unveiled their formation by exhibiting the typical surface plasmon absorption maxima at 522 nm. The size of T-GNPs was found to be 10.86 ± 0.6 nm. T-GNPs were characterised by dynamic light scattering, zeta potential, transmission electron microscopy analysis and Fourier transform infrared spectroscopy. T-GNPs were further investigated for their anti-cancer activity against human lung carcinoma cell line (A 549) and human cervical cancer cell line wherein the IC50 values were found to be 0.286 and 0.200 mM, respectively. T-GNPs inhibited the growth of cancer cells by generating ROS and inducing apoptosis. T-GNPs were found highly effective by virtue of their size, metallic property and capping molecules. Thus, this study opens up the prospects of using nutraceutical (tomato juice) as nutratherapeutic agent (T-GNPs) against critical diseases like lung cancer and cervical cancer.

Inspec keywords: particle size; ultraviolet spectra; cancer; spectrochemical analysis; electrokinetic effects; nanofabrication; transmission electron microscopy; gold; Fourier transform infrared spectra; cellular biophysics; nanomedicine; nanoparticles; visible spectra

Other keywords: reducing agent; anticancer activity; tomato juice; tetrachloroauric acid; human cervical cancer cell line; surface plasmon absorption; nutratherapeutic agent; cancer therapeutics; Au; lung cancer; transmission electron microscopy analysis; UV-visible absorption spectroscopy; zeta potential; dynamic light scattering; human lung carcinoma cell line; Fourier transform infrared spectroscopy; tomato-mediated synthesised gold nanoparticles

Subjects: Electrochemistry and electrophoresis; Other methods of nanofabrication; Patient care and treatment; Electromagnetic radiation spectrometry (chemical analysis); Cellular biophysics; Nanotechnology applications in biomedicine

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