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access icon free Evaluation of antifungal effect of iron-oxide nanoparticles against different Candida species

  • Author(s): Nazanin Sadat Seddighi 1 ; Samira Salari 2, 3 ; Ali Raza Izadi 4
    • View affiliations
  • Source: Volume 11, Issue 7, October 2017, p. 883 – 888
    DOI:  10.1049/iet-nbt.2017.0025 , Print ISSN 1751-8741, Online ISSN 1751-875X
© The Institution of Engineering and Technology
Received 09/02/2017, Accepted 20/06/2017, Revised 22/04/2017, Published 19/07/2017

Iron-oxide nanoparticles (IONPs) have been widely favoured due to their biodegradable, low cytotoxic effects and having reactive surface which can be altered with biocompatible coatings. Considering various medical applications of IONPs, the authors were encouraged to study whether IONPs could be effective against fungal infections caused by Candida species. In this study, IONPs were characterised by scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and vibrating sample magnetometer. The goal of this study was to evaluate the antifungal activity of IONPs against different Candida spp. compared with fluconazole (FLC). IONPs were spherical with the size of 30–40 nm. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of IONPs ranged from 62.5 to 500 µg/ml and 500 to 1000 μg/ml, respectively. The MIC and MFC of FLC were in range of 16–128 μg/ml and 64–512 μg/ml, respectively. The growth inhibition value indicated that Candida tropicalis, Candida albicans and Candida glabrata spp. were most susceptible to IONPs. The finding showed that the IONPs possessed antifungal potential against pathogenic Candida spp. and could inhibit the growth of all the tested Candida spp. Further studies, both in vitro and in vivo (including susceptibility, toxicity, Probability of kill (PK) and efficacy studies) are needed to determine whether IONPs are suitable for medicinal purposes.

Inspec keywords: nanomedicine; cellular biophysics; nanoparticles; biomedical materials; iron compounds; toxicology; drugs; scanning electron microscopy; microorganisms; X-ray diffraction; Fourier transform infrared spectra

Other keywords: minimum fungicidal concentration; antifungal properties; immunocompromised hosts; reactive surface; Candida species; chemical drugs; vibrating sample magnetometer; medical applications; biocompatible coatings; broth microdilution; cytotoxic effects; Fe3O4; fungal infections; antifungal effect; Candida Albicans; Candidiasis; minimal inhibitory concentration; antifungal drugs; Candida glabrata; Candida tropicalis; Fourier transform infrared spectroscopy; antifungal potential; biodegradable effects; antifungal activity; IONP; side effects; resistant organisms; scanning electron microscopy; X-ray diffraction; iron-oxide nanoparticles; disc diffusion

Subjects: Infrared and Raman spectra in inorganic crystals; Cellular biophysics; Structure of solid clusters, nanoparticles, nanotubes and nanostructured materials; Optical properties of other inorganic semiconductors and insulators (thin films, low-dimensional and nanoscale structures); Nanotechnology applications in biomedicine; Biomedical materials

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