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access icon free Synthesis and characterisation of neem leaf extract, 2, 3-dehydrosalanol and quercetin dihydrate mediated silver nano particles for therapeutic applications

The utility of green silver nanoparticles (AgNPs) in veterinary medicine is steadily increasing as they have many therapeutic applications against pathogens and arthropods of livestock. In this study, green AgNPs using neem (N-AgNPs), 2,3-dehydrosalanol (2,3-DHS-AgNPs) and quercetin dihydrate (QDH-AgNPs) were synthesised and characterised. Synthesised compounds were characterised by UV-Vis spectroscopy and the peak absorbance was recorded at 370 nm for neem extract. For N-AgNPs, 2,3-DHS-AgNPs and QDH-AgNPs, the maximum absorbance peaks were at 430, 230 and 220 nm, respectively. The FTIR analysis confirmed the synthesis of green AgNPs. The XRD pattern of N-AgNPs showed the peaks corresponding to whole spectra of 2 θ values ranging from 10–80. The relatively higher intensity of (111, 222) planes in face centred cubic crystalline structure supports the formation of synthesised AgNPs. In DLS analysis, the hydrodynamic diameter of neem leaf extract was found to be 259.8 nm, followed by 5.3, 6.7 and 261.8 nm for 2,3-DHS-AgNPs, N-AgNPs and QDH-AgNPs, respectively. Based on the transmission electron microscopy and scanning electron microscopy image analyses, confirmed the formation of N-AgNPs, 2,3-DHS-AgNPs and QDH-AgNPs. These eco-friendly phyto-AgNPs may be of use as an effective alternative to chemical control methods against the arthropods of livestock.

Inspec keywords: X-ray diffraction; silver; nanofabrication; visible spectra; veterinary medicine; ultraviolet spectra; aggregation; Fourier transform infrared spectra; light scattering; transmission electron microscopy; biomedical materials; nanoparticles; nanomedicine; scanning electron microscopy

Other keywords: arthropod infesting livestock; green silver nanoparticles; scanning electron microscopy; (222) planes; pencil head shape; hydrodynamic diameter; hexagonal shape; Fourier transformed infrared analysis; dynamic light scattering; cuboid shape; Azadirachta indica; aqueous neem leaf extract; veterinary medicine; in-vitro antiectoparasitic activity; X-ray diffraction; 2,3-dehydrosalanol mediated silver nanoparticles; in-vivo antiectoparasitic activity; aggregation; quercetin dihydrate mediated silver nanoparticles; therapeutic applications; (111) planes; face centred cubic crystalline structure; transmission electron microscopy; UV-visible spectroscopy; Ag

Subjects: Brillouin and Rayleigh scattering; other light scattering (condensed matter); Biomedical materials; Nanotechnology applications in biomedicine; Other methods of nanofabrication; Low-dimensional structures: growth, structure and nonelectronic properties; Visible and ultraviolet spectra of metals, semimetals, and alloys; Optical properties of metals and metallic alloys (thin films, low-dimensional and nanoscale structures); Structure of solid clusters, nanoparticles, nanotubes and nanostructured materials; Infrared and Raman spectra in metals

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