access icon free Design and fabrication of field-effect biosensors for biochemical detection

Biochemically sensitive field-effect sensors are fabricated with simplified chip technology. Its fabrication process flow is designed based on metal gate complementary metal-oxide semiconductor technology, in which only six pattern masks are employed. The sensors are measured as field modulation resistors since they are made in its depletion mode. The milliampere magnitude response of conducting currents from certain biochemical materials achieves distinct sensitivity when measured on our fabricated sensors with different sensitive areas of W/L = 4.2 and 20.0. To check the stability of the sensor, up to 20 repeated tests are conducted on the same sensor chip operated in its three states, in which no materials (blank state, called ‘blank’), pure water and biochemical materials are coated on its gate dielectric film, respectively. Measured results show that the response currents for certain materials are distributed in certain current range. Taking the response current of blank as a reference value, the response current of pure water is positive but very close to that of blank because of the small electric dipole properties of pure water. However, the response current of biochemical materials are negative and far apart from that of blank, because the biochemical materials have large electric dipole properties and clearly show measurement resolution.

Inspec keywords: chemical sensors; CMOS integrated circuits; MOSFET; biosensors; water; dielectric thin films; biochemistry

Other keywords: sensor stability; gate dielectric film; biochemical detection; simplified chip technology; pure water; field-effect biosensors; pattern masks; response currents; sensitivity; field modulation resistors; biochemical materials; fabrication process flow; metal gate complementary metal-oxide semiconductor technology; electric dipole properties

Subjects: Physical chemistry of biomolecular solutions and condensed states; Biosensors; Chemical sensors; Biosensors; CMOS integrated circuits; Insulated gate field effect transistors; Chemical sensors; Biological engineering and techniques; Chemical variables measurement

References

    1. 1)
    2. 2)
    3. 3)
    4. 4)
      • 29. Patolsky, F., Lieber, C.M.: ‘Nano wires: nanosensors’, Mater. Today, 2005, 8, (5), pp. 2028.
    5. 5)
      • 23. Santiram, K., Bhanu, P.V.: ‘Design and modeling of ISFET for pH sensing’. IEEE Conf. TENCON 2007, 30 October–2 November 2007, pp. 14.
    6. 6)
      • 20. Anran, R., Lu, N., Xiuli, L., et al: ‘Label-free DNA detection based on silicon nanowires’. Sixteenth Int. Conf. Solid-State Sensors, Actuators and Microsystems, 5–9 June 2011, pp. 22712274.
    7. 7)
    8. 8)
    9. 9)
    10. 10)
    11. 11)
      • 22. Naimi, S.E., Hajji, B., Habbani, Y., Humenyuk, I., Launay, J., Temple-Boyer, P.: ‘Modeling of the pH-chemfet response and using genetic algorithm as extraction parameters method’. Faible Tension Faible Consommation (FTFC), 30 May–1 June 2011, pp. 103106.
    12. 12)
    13. 13)
    14. 14)
    15. 15)
    16. 16)
    17. 17)
    18. 18)
      • 26. Tomaszewski, D., Yang, C., Jaroszewicz, B., Zaborowski, M., Grabiec, P., Pijanowska, D.G.: ‘Electrical characterization of ISFETs’, J. Telecommun. Inf. Technol., 2007, 3, pp. 5560.
    19. 19)
    20. 20)
    21. 21)
    22. 22)
    23. 23)
    24. 24)
    25. 25)
    26. 26)
    27. 27)
      • 4. Goh, Z., Georgiou, P., Constandinou, T.G., Prodromakis, T., Toumazou, C.: ‘A CMOS-based lab-on-chip array for combined magnetic manipulation and opto-chemical sensing’. IEEE Int. Symp. Circuits and Systems (ISCAS), 2011, pp. 19972000.
    28. 28)
    29. 29)
    30. 30)
      • 13. Yuan, S., Fan, X., Wang, Z., Li, X.: ‘Biochemical sensitive field-effect sensors for Schistosoma cercariae detection’. IEIT Proc. Int. Workshop on Engineering Application Research, 2011, pp. 265268.
http://iet.metastore.ingenta.com/content/journals/10.1049/iet-nbt.2013.0061
Loading

Related content

content/journals/10.1049/iet-nbt.2013.0061
pub_keyword,iet_inspecKeyword,pub_concept
6
6
Loading