access icon free Synthesis of hierarchical porous bioactive glasses for bone tissue regeneration

A novel hierarchical porous bioactive glasses were synthesised with cattail stem and triblock polyethylene oxide–propylene oxide block copolymer (P123) as macroporous template and mesoporous template, respectively. The structural and textural properties of materials were characterised by X-ray diffraction, scanning electron microscope, Fourier transform infrared spectroscopy, nitrogen adsorption–desorption, energy dispersive spectrometer and vibrating sample magnetometer technique. The results reveal the bioglasses possess multilevel porous structure with the macroporous size about 50 μm and the mesopore with the diameter of 3.86 nm. Furthermore, metformin HCl was used as the model drug. The drug release kinetics and hydroxyapatite (HAP, (Ca10(PO4)6(OH)2)) inducing-growth ability of the composites were studied, respectively. The system exhibits the fast HAP inducing-growth ability and long-term drug delivery, making them a good candidate for bone tissue regeneration.

Inspec keywords: nanofabrication; nanomedicine; X-ray chemical analysis; drugs; surface texture; nanoporous materials; Fourier transform spectra; phosphate glasses; bone; desorption; drug delivery systems; mesoporous materials; X-ray diffraction; tissue engineering; adsorption; infrared spectra; bioceramics; porosity; calcium compounds; scanning electron microscopy; nitrogen

Other keywords: multilevel porous structure; hydroxyapatite inducing-growth ability; Ca10(PO4)6(OH)2; triblock polyethylene oxide-propylene oxide block copolymer P123; N2; vibrating sample magnetometer; Fourier transform infrared spectroscopy; long-term drug delivery; macroporous template; hierarchical porous bioactive glasses; macroporous size; P123; nitrogen adsorption-desorption; size 3.86 nm; drug release kinetics; bone tissue regeneration; textural properties; metformin HCl; structural properties; scanning electron microscopy; X-ray diffraction; cattail stem; energy dispersive spectrometer; mesoporous template

Subjects: Infrared and Raman spectra in disordered solids (inc. glasses and polymers); Structure of solid clusters, nanoparticles, nanotubes and nanostructured materials; Biomedical materials; Electromagnetic radiation spectrometry (chemical analysis); Structure of glasses; Sorption and accommodation coefficients (surface chemistry); Methods of nanofabrication and processing; Nanotechnology applications in biomedicine; Patient care and treatment; Adsorption and desorption kinetics; evaporation and condensation; Cold working, work hardening; post-deformation annealing, recovery and recrystallisation; textures; Preparation of glasses; Structure of powders and porous materials; Solid surface structure; Patient care and treatment

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http://iet.metastore.ingenta.com/content/journals/10.1049/iet-nbt.2013.0054
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