Synthesis and characterisation of poly(lactide-co-glycolide) nanospheres using vitamin E emulsifier prepared through one-step oil-in-water emulsion and solvent evaporation techniques

Masoud Mozafari

Synthesis and characterisation of poly(lactide-co-glycolide) nanospheres using vitamin E emulsifier prepared through one-step oil-in-water emulsion and solvent evaporation techniques

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Author(s): Masoud Mozafari ¹
- Affiliations: 1: Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 14155-4777, Tehran, Iran
Source: Volume 8, Issue 4, December 2014, p. 257 – 262
DOI: 10.1049/iet-nbt.2013.0053 , Print ISSN 1751-8741, Online ISSN 1751-875X

Received 04/08/2013, Accepted 01/11/2013, Revised 10/10/2013, Published 12/02/2014

Nanoparticulate drug delivery systems are of considerable therapeutic interest for delivery of drugs across from the blood–brain barrier. In this study, the ability of sodium chloride (NaCl) and different percentages of a water-soluble form of natural vitamin E, on the formation of poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs), as a potential carrier for drug delivery, was investigated. According to the obtained results, by increasing the percentage of natural vitamin E, the average particle size decreased and the range of diameters came closer. After using 0.26 w/v % vitamin E, the average size of the PLGA particles became <100 nm. Moreover, the particles containing NaCl led to the formation of even smaller particles. In addition, no obvious cytotoxicity was observed at various natural vitamin E amounts in one and three days, and the modified PLGA NPs could be considered biocompatible since they showed a little decrease in cellular viability.

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Synthesis and characterisation of poly(lactide-co-glycolide) nanospheres using vitamin E emulsifier prepared through one-step oil-in-water emulsion and solvent evaporation techniques

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