RT Journal Article
A1 Munira Raja
A1 David Donaghy
A1 Laura Gonzalez-Macia
A1 Antony J. Killard

PB iet
T1 Design and simulation of a high-gain organic operational amplifier for use in quantification of cholesterol in low-cost point-of-care devices
JN IET Circuits, Devices & Systems
VO 11
IS 5
SP 504
OP 511
AB This paper presents circuit design and simulations of a high gain organic Op-Amp, for use in quantification of real cholesterol, in the range of 1–9 mM. A 7-stage inverter chain is added onto the design so as to enhance the amplifier gain. The circuit adapts p-channel transistors only (PMOS) design architecture with saturated loads, simulated on a conventional platform, using appropriate OTFT model and associated parameters. The effect of variation in threshold voltage on circuit operation is also examined. For a supply voltage of ±15 V, the DC output voltage is found to be within an acceptable range of −1 V to −12.5 V, with a highest open loop gain of 83 dB. The closed loop gain is also in agreement with theoretical values, in the range of 1.5 dB to 39 dB, with corresponding bandwidths of 770 Hz to 275 Hz respectively. The latter gain of 39 dB and/or gain-bandwidth product of 10.63 kHz is currently the highest reported in the literature, for this lower supply voltage. The amplifier offers adequate quantification factor, with linear sensitivity of −0.7 V/mM. This paper is the first to adapt organic circuit designs in quantification of cholesterol, with promising outputs, for implementation in low-cost sensor systems.
K1 low-cost point-of-care devices
K1 seven-stage inverter chain
K1 amplifier gain
K1 bandwidth 10.63 kHz
K1 high-gain organic operational amplifier
K1 voltage -1 V to -12.5 V
K1 organic transistor model
K1 organic circuit designs
K1 threshold voltage
K1 low-cost sensor systems
K1 gain 83 dB
K1 gain 39 dB
K1 bandwidth 770 Hz to 275 Hz
K1 cholesterol quantification
K1 PMOS design architecture
DO https://doi.org/10.1049/iet-cds.2016.0500
UL https://digital-library.theiet.org/;jsessionid=2jhyt6j5hvux6.x-iet-live-01content/journals/10.1049/iet-cds.2016.0500
LA English
SN 1751-858X
YR 2017
OL EN