High rates of fuel consumption are not required by insulating motifs to suppress retroactivity in biochemical circuits
- Author(s): Abhishek Deshpande 1, 2 and Thomas E. Ouldridge 3
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View affiliations
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Affiliations:
1:
Department of Mathematics , Imperial College London , London SW7 2AZ , UK ;
2: School of Technology and Computer Science , Tata Institute of Fundamental Research , Mumbai 400005 , India ;
3: Department of Bioengineering , Imperial College London , London SW7 2AZ , UK
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Affiliations:
1:
Department of Mathematics , Imperial College London , London SW7 2AZ , UK ;
- Source:
Volume 1, Issue 2,
December
2017,
p.
86 – 99
DOI: 10.1049/enb.2017.0017 , Online ISSN 2398-6182
Retroactivity arises when the coupling of a molecular network to a downstream network results in signal propagation back from to . The phenomenon represents a breakdown in modularity of biochemical circuits and hampers the rational design of complex functional networks. Considering simple models of signal-transduction architectures, the authors demonstrate the strong dependence of retroactivity on the properties of the upstream system, and explore the cost and efficacy of fuel-consuming insulating motifs that can mitigate retroactive effects. They find that simple insulating motifs can suppress retroactivity at a low fuel cost by coupling only weakly to the upstream system . However, this design approach reduces the signalling network's robustness to perturbations from leak reactions, and potentially compromises its ability to respond to rapidly varying signals.
Inspec keywords: biochemistry; biomolecular electronics; molecular biophysics; biotechnology
Other keywords: retroactivity; fuel consumption; signal transduction; complex functional networks; biochemical circuits; insulating motifs
Subjects: Biomolecular electronics; Biophysical instrumentation and techniques; Physical chemistry of biomolecular solutions and condensed states
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