%0 Electronic Article %A Tianyi Wang %+ Bio-Manufacturing Programme, Singapore Institute of Manufacturing Technology, Singapore %A Jiewei Lew %+ Bio-Manufacturing Programme, Singapore Institute of Manufacturing Technology, Singapore %A Jayaraman Premkumar %+ Department of Biomedical Engineering, National University of Singapore, Singapore %A Chueh Loo Poh %+ Department of Biomedical Engineering, National University of Singapore, Singapore %A May Win Naing %+ Bio-Manufacturing Programme, Singapore Institute of Manufacturing Technology, Singapore %K biocompatibility %K healthcare materials %K collagen structure %K prokaryotic hosts %K recombinant human collagen %K immunogenicity %K animal collagen %K eukaryotic hosts %K biomimicry %K animal sources %K biomedical research %X Collagen, which is often used in healthcare materials and biomedical research, is largely extracted from animal sources. Recombinant human collagen has the potential to be a promising alternative to animal collagen which has many shortcomings, including immunogenicity and lack of biocompatibility. Currently, recombinant human collagen has been expressed in both eukaryotic and prokaryotic hosts with varying degrees of success. One issue with recombinant collagen across all hosts is the inability to achieve full length collagen with native amounts of post-translational modifications, prompting much exciting research in this direction. There has also been much effort in improving yield and biomimicry of recombinant collagen. This review discusses collagen structure and current methods for extracting animal collagen, before introducing current research in synthesising recombinant human collagen in various hosts, and finally highlighting challenges in the field. %T Production of recombinant collagen: state of the art and challenges %B Engineering Biology %D June 2017 %V 1 %N 1 %P 18-23 %I Institution of Engineering and Technology %U https://digital-library.theiet.org/;jsessionid=ber65l00f70u.x-iet-live-01content/journals/10.1049/enb.2017.0003 %G EN