Ultra-sensitive immunoassay using VCSEL detection system
Ultra-sensitive immunoassay using VCSEL detection system
- Author(s): C.F.R. Mateus ; M.C.Y. Huang ; C.J. Chang-Hasnain ; J.E. Foley ; R. Beatty ; P. Li ; B.T. Cunningham
- DOI: 10.1049/el:20040491
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- Author(s): C.F.R. Mateus 1 ; M.C.Y. Huang 1 ; C.J. Chang-Hasnain 1 ; J.E. Foley 2 ; R. Beatty 3 ; P. Li 4 ; B.T. Cunningham 4
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View affiliations
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Affiliations:
1: Electrical Engineering and Computer Sciences Department, University of California, Berkeley, USA
2: Bioengineering Department, University of California, Berkeley, USA
3: Molecular and Cell Biology Department, University of California, Berkeley, USA
4: Molecular and Cell Biology Department, SRU Biosystems, Woburn, USA
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Affiliations:
1: Electrical Engineering and Computer Sciences Department, University of California, Berkeley, USA
- Source:
Volume 40, Issue 11,
27 May 2004,
p.
649 – 651
DOI: 10.1049/el:20040491 , Print ISSN 0013-5194, Online ISSN 1350-911X
Highly sensitive protein characterisation on a new label-free biosensor system is reported. The system consists of a VCSEL, a plastic guided mode resonant filter and two pin detectors. It is suitable for measuring both static and dynamic interaction among proteins and can detect an antigen concentration as low as 1 pg/ml (6.7 femtoMolar).
Inspec keywords: surface emitting lasers; resonator filters; biosensors; molecular biophysics; proteins
Other keywords:
Subjects: Biosensors; Laser resonators and cavities; Molecular biophysics; Laser resonators and cavities; Biosensors
References
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- Mateus, C.F.R., Hung, J.S.P., Yao, H., Hasnain, G., Kuo, C., Liao, A., Li, P., Cuningham, B.T., Chang-Hasnain, C.J.: `Ultra-compact, high sensitivity label-free biosensor using VCSEL', 2003 Conf. on Lasers and Electro-Optics - CLEO, 2003, Baltimore, MD, USA.
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