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Conductive organic materials for DNA biosensors

Conductive organic materials for DNA biosensors

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Conductive organic materials have attracted great interest due to their excellent electronic and biochemical properties, which make them suitable for promising applications in chemical and biological sensing. With many advantages like labelfree and easy fabrication, DNA biosensors based on conductive organic materials have shown significant benefit for the rapid and highly sensitive genetic detection. Organic DNA sensors can be mainly divided into two types, which are based on electrochemical detection and organic thin-film transistors, respectively. This chapter gives a comprehensive description to these two types of DNA sensors, while the principles of sensors, relative organic materials, detection methods, transduction mechanisms, and their pros and cons are well addressed in detail. Moreover, some new developments and future perspectives in this field are also discussed.

Chapter Contents:

  • Abstract
  • 3.1 Introduction
  • 3.2 Electrochemical DNA sensors based on organic conducting polymers
  • 3.2.1 Brief description
  • 3.2.2 DNA immobilization methods
  • 3.2.2.1 Electro-polymerization entrapment method
  • 3.2.2.2 Layer-by-layer method
  • 3.2.2.3 Cross-linker and affinity interaction method
  • 3.2.3 Transduction mechanisms
  • 3.2.3.1 Amperometric and voltammetric detection
  • 3.2.3.2 Impedimetric detection
  • 3.2.3.3 Conductometric and chronocoulometric detection
  • 3.2.4 DNA sensing
  • 3.2.4.1 DNA damage detection
  • 3.2.4.2 DNA mismatch detection
  • 3.2.4.3 Complementary DNA detection
  • 3.3 DNA sensors based on OTFTs
  • 3.3.1 Brief description
  • 3.3.2 Mechanisms of OTFT sensors for DNA
  • 3.3.2.1 Traditional OFET
  • 3.3.2.2 Concept-new type OTFTs
  • 3.3.2.3 The DNA sensing principles
  • 3.3.3 OTFT sensors for DNA
  • 3.3.3.1 Traditional OFET-based DNA sensors
  • 3.3.3.2 Concept-new type OTFT-based DNA sensors
  • 3.4 Conclusions
  • References

Inspec keywords: conducting materials; biosensors; DNA; transducers

Other keywords: conductive organic material; organic DNA biosensor; electronic property; chemical sensing; electrochemical detection; biochemical property; biological sensing; organic thin-film transistor; transduction mechanism

Subjects: Biosensors; Biosensors; Molecular biophysics

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